England collapsed as skipper Carlos Brathwaite and spinner Sunil Narine applied the brakes to win by 21 runs.
Alex Hales struck a blazing 43 as England started strongly but the hosts fell to 68-4. Buttler and Bairstow out on 50 for the 5th wicket but they crumbled and were all out for 155.
Earlier, West Indies made 176 for nine after Chris Gayle (40) and Lewis (51) got the tourists off to a flying start, putting on 77 for the first wicket.
West Indies 176 for 9 (Lewis 51, Gayle 40, Rashid 3-25, Plunkett 3-27) beat England 155 (Hales 43, Brathwaite 3-20, Williams 3-35, Narine 2-15) by 21 runs.
Matches Tagged in ClipDex2017 ENG v WIN Only T20
Series Tagged in ClipDex2017 ENG v WIN T20 series
Players Tagged in ClipDexGayle, Christopher H Nurse, Ashley Renaldo Buttler, Joseph Charles Curran, Thomas K Williams, Kesrick O K Bairstow, Jonathan M Hales, Alex Daniel Brathwaite, Carlos R Lewis, Evin Narine, Sunil P Plunkett, Liam E Rashid, Adil U
Grounds Tagged in ClipDexRiverside Ground
Categories Tagged in ClipDexLimited Overs (ODI & T20)