Shikhar Dhawan's 39-ball 72 set up India's massive first-innings total and Bhuvneshwar Kumar's five-wicket haul ensured South Africa went down by 28 runs.
India posted 203-5 as Dhawan put India on the front foot. Debutant Junior Dala was the pick of the South African bowlers with 2-47.
Bhuvneshwar Kumar finished with career-best figures of 5-24 as South Africa stumbled to 175-9.
India 203 for 5 (Dhawan 72, Dala 2-47) beat South Africa 175 for 9 (Hendricks 70, Behardien 39, Bhuvneshwar 5-24) by 28 runs.
Matches Tagged in ClipDex2018 RSA v IND 1st T20
Series Tagged in ClipDex2018 RSA v IND T20 series
Players Tagged in ClipDexHendricks, Reeza R Bumrah, Jasprit J Dhawan, Shikhar Chahal, Yuzvendra S Kohli, Virat Behardien, Farhaan Duminy, Jean-Paul Kumar, Bhuvneshwar
Grounds Tagged in ClipDexNew Wanderers Stadium
Categories Tagged in ClipDexLimited Overs (ODI & T20)